Showing posts with label applied research. Show all posts
Showing posts with label applied research. Show all posts

Sunday, August 16, 2009

Bye Bye Love

(Pictured from left Professor Mel Rosenberg, Professor Danny Levitan, Rector, Tel Aviv University)

Bye Bye Love

I have spent most of my life at Tel Aviv University, student, lecturer, professor. I started out 36 years ago as a starry-eyed young M.Sc. student, right after the Yom Kippur war. Lat week I submitted my letter requesting early retirement. There are many reasons for my desire to retire eleven years early, some stemming from my own personal journey, which has been diverging from the university's path for some years. Though I am critical of what is transpiring on campus, I love the university, and it has been an integral part of me. Here I fell in love, became a scientist, and enjoyed a career as scientist and inventor.

Yesterday I chanced upon the log book I kept as a Ph.D. student. On Nov. 18th , 1979, I carried out a little experiment which showed how readily bacterial cells become attached to oil droplets. It formed the basis for my thesis work, and a significant part of my subsequent career. http://garfield.library.upenn.edu/classics1991/A1991FE76400001.pdf

As a retiree, I will maintain an office here at the Medical Faculty, and a research lab, and I plan to continue my current studies on bad breath and related topics. And of course, not being involved in university administration will hopefully allow more time to write children's stories and perform and sing for both adults and kids. See http://www.melrosenberg.com/ to learn about everything I love to do.


Thursday, June 18, 2009

Save Your Breath - A general book on how to solve bad breath


Save your Breath

"Save Your Breath" is a book on bad breath that I have written for the general public. I wish me luck! I have already sold over 120 books and it isn't even published yet. This book is very valuable because it's an easy read and yet extremely informative and explanatory. I hope it will better many the many people l around the globe who suffer from issues of bad breath on a daily basis. "Save Your Breath" is being copy edited and should be available in August via my website www.smellwell.com

It's hard for me to believe, but I started writing this book in 1989, on an old Wang word processor (those don't exist anymore, nor does the Wang Laboratories). So why did it take me two decades to write this book?

During the last twenty years I have done a lot of research, published many papers (including one in Scientific America), consulted thousands of individuals in Canada, England and Israel, and lectured around the world. And yet, I have found that one of the most difficult challenges that continues to face me and other professionals in this field is dealing with the emotional concerns surrounding the problem. I have addressed these at length in the book, together with my best tips for keeping breath fresh and good.

My colleague and soul mate Dr. Chris McCullock (whom I spent quality time with on my recent visit to Toronto)wrote a splendid Foreword for the book. It's much to kind, I but I can live with "kind".

Sunday, May 31, 2009

A Trip to Dortmund



My Trip to Dortmund

Traveling to Germany is always an issue for me. For decades, I wouldn't go at all. Then, when I was about forty-five, I broke the ice and started going there for business. I found three things: i. A lovely country; ii. Nice people (with a few exceptions, like anywhere); iii. Ghosts. I keep coming back to the war, wherever I am. Where did the Jews live here? Where were they picked up – here, at this very train station? Sometimes there are stark reminders. For example, when we saw someone selling silver synagogue ornaments from a stall in Berlin (I freaked out). Or when I was given a body search by a German soldier guarding the basement museum in downtown Berlin underneath the concrete slab monument (the frisking was particularly disturbing, I broke out in a cold sweat).

Somewhere in my collective memory I am wearing the pajamas of a concentration camp inmate. Non Jewish people do not seem to understand that Jews have a common fabric. I am often asked there (and other places), "Did you have relatives in the war?" The answer is that I had no close relatives, but all the millions of Jews that were shot and gassed are my relatives. To paraphrase Humboldt, we are all a single entity, a single organism. Perhaps that is why the Jewish community is so proud of its successful offspring, and equally outraged at miscreants such as Madoff, whether or not we invested with the goniff.

As usual I digress. So here we are in Germany (two weeks ago) for the 8th international conference on breath odor research. The meeting is in Dortmund, a city that appears to have lots of trees, fields of rapeseed, and no downtown. To make matters worse, the conference is near the university which is itself out of town (if you call it a town), so much for geography.


The meeting has two parts. The first has to do with bad breath and is organized by ISBOR – the International Society for Breath Odor Research. This is a society that I organized together with Prof. Daniel van Steenberghe in 1995. The second meeting is about using the non-smelly gases from the breath to diagnose medical conditions (such as asthma, diabetes, and even lung cancer). This part of the meeting is organized by the IABR – the International Association for Breath Odor.

During the smelly part of the meeting, the old rivalries between competing dogmas erupt. On the surface, it appears to be about science, but it is just as much about personal enmities and envities. Is bad breath only due to sulfur gases or are many gases involved? Is periodontal disease an important factor in causing bad breath? Which is more important – odor judge scores or instrumental sulfide measurements? Is the halimeter useful or not (I developed the application, so I think it is). As in other scientific meetings, friends of the meeting organizers are invited to speak, others are excluded. Scientists can on occasion be very authoritative and unpleasant.
You can check out my newly designed website http://www.smellwell.com/ for interesting articles on smell and more updates on, of course, bad breath. Also, read about OkayToKiss, the new, patent-pending saliva test, my team has been working on in the lab. http://http//sciencenow.sciencemag.org/cgi/content/full/2009/522/1

After the meeting, Dr. Nir Sterer (postdoc in my lab) and Yael Gov (star technician) and I head to Cologne to visit my friends Jehudi and Iris, chill out, and play tourists. With our hosts to show us around town, we are treated to a marvelous time. We heard some excellent traditional jazz, and I even sat in (on piano) with a great trio playing outside!!

One of the most amazing attractions in Cologne (at least for me) is the chocolate museum. I am told that there are only two other museums dedicated to this divine treat – in Barcelona and Brussels, if I am not mistaken.

My curiosity here is overwhelming – I have to know how chocolate is REALLY processed. I drive the guides crazy but they are kind in answering my many questions. They even give me a whole bunch of roasted cocoa beans (which I am enjoying one by one).

I discovered several years ago that dark chocolate helps me swallow my food (I have a rare condition known as acchalasia, in which the muscles in the esophagus are not prompted to squeeze the food along). We are now doing a study at Ichilov Hospital to see whether it helps others (initial results are encouraging) and I am trying to track down Sergey Brin to get him to fund a study on the effect of dark chocolate on parkinsonism (PD).

Wherever I go, I compare and stock up on dark chocolate. My favorite tasting one is a 72% bar hailing from Italy (and not expensive!!). I am now in Toronto where one can buy 100% baker's chocolate. I just did. That's a little much for even my palate!

Thursday, November 20, 2008

Blog on Academia and Industry Answer to Janet

Skip to article Dear Janet,

To: JANET RAE-DUPREE

Dear Janet,

You recently (Sept. 6th, 2008) wrote an article in the New York Times entitled on universities and intellectual property in the US. This article was circulated among senior professors at my university, and had a bemused read.

Let's start with the basics. University academics have egos that range from large to XXXL. They (myself included, of course) want to be internationally acknowledged for their discoveries, theories, inventions and writings. They fight about who was the first one to detect this or that, and pine for decades when their work is not acknowledged appropriately. If scientists and other professors did not have such big egos, then perhaps no one would mind if an important paper came out written by "a group of modest folk singers at our department". Trust me, people fight hard and long not only about who gets on an academic paper, but the order of the authors as well. Show me an anonymous scientific article in a good journal. . Read James Watson's "The Double Helix" for a candid account of the egos involved in deciphering the holy grail of biology. It was not about money, it was about fame. Then, maybe money.

But that was in the 1950s, and to be frank, Janet, times have changed. In those halcyon days, relatively few people made a great deal of money, and perhaps wealth served as less of a criterion for success than it does today. Furthermore, for scientists, research money was once more widely available for so-called basic projects than it is currently. Nowadays, I agree with you that money plays a major role in academic decisions. But in this brave, new world, money seems to play a greater role in every other facet of our lives as well, including running for public office. Being a kind, knowledgeable and/or worthy human being doesn't cut it without a fat bank account.

So, at least in that sense, universities are a reflection of society in general. Society has changed, and with it our campuses. In the 1970s when I entered Tel Aviv University, there was abundant grass (the kind you step on as well), large open spaces, and a building every now and then (I even got a slight lightning shock in 1974 walking between classes!). Now, more and less savory people with the other kind of green have donated enough money for a myriad of concrete structures with their names eternally affixed to them. A kind of name graveyard. So we have the Peter Pan building for this and the Peter, Paul and Mary faculty for that. Most of these benevolent donors fought with the university to get their names emblazoned in as large a font as possible on the buildings. In at least one instance, the couple donating the building died, so they shut up that entrance and built a new one with somebody else's name on it. We don't have a single building, faculty or even department, named after anonymous. Everyone wants their due. By the way, few of these donors pay for the upkeep of these concrete edifices. Some of the buildings are beautiful, some are ugly. But one thing is certain – there is less grass on campus. And it's easy to get lost among the concrete, even for someone like me who has been here since 1973.

But again I digress. As goes the world, so goes academia. Universities are expensive elephants. And students balk at paying tuition that even approaches the cost of teaching them. They can make millions in their post campus careers, based on what we have taught them, and don't owe us a nickel. Perhaps we should be charging them royalties?

So where are we going to get our money? Some of it comes from government funds. This is a dwindling source everywhere. Salaries rise, the cost of equipment rises, and public research money trickles. So even the most esoteric of researchers, interested in obscure ancient tongues, or with a penchant for studying the writings of a forgotten thirteen century cleric, or perhaps a scientist studying why worms are brown, all have to compete with 'sexier' research topics. If their research is not "interesting", "timely", "poignant", etc., who will fund it? As a case in point, we have one very successful professor who has made a wild international career based on disputing religious events that did or did not take place 2,500 years ago. I personally could not care less whether King David was 4 foot 3, had a mustache, and ate plums. But apparently others think it is the hottest topic on earth. So, these days, there is a big impetus on all academics to perform research that can sell, on one level or another. Poignantly, research journals (which also need to sell subscriptions to survive) have changed completely since the 1950s, and are always on the lookout for sensational articles that will increase their readership. And we need to publish in them in order to advance in our careers, and draw university salary.

In most cases, researchers tend to do their own thing. They perform research of lesser and greater significance, going where their noses take them, publish their results more-or-less objectively (but, like any door-to-door salesman, make the best of whatever stock they have in hand). They pitch their research proposals to funding agencies. Researchers hope that they will be judged and promoted fairly (this does not always happen, since academic life is rife with politics). Some young academics depend on moral support from their former mentors (and are reluctant to forge into new areas). Some receive tenure, only to freeze or dry up. Others have a spectacular career, full of discovery and insight.

All academics are under increasing pressure to look good, to bring in significant research funds, to publish findings in worthy journals. The temptation is there to round corners, but still there are very few fraudulent academics.

Janet, the problems that you discuss must be considered in the context of our changing world. The careers of many academics these days do involve technologies that overlap with the commercial world. After all, the modern world is a highly technological one. You can get along quite well nowadays without reciting a single line of Shakespeare, but if you can't google, e-mail or text-message, you are a lost soul.

Those of us academics who work side-by-side with the multinational monsters, the pharma giants, the mammoth companies of food, energy, etc. have to be doubly careful. Yes, Janet, it is easy to fall prey to commercial interests when you are running a university lab, and need the support. You do need to be doubly careful. But can you blame universities for wanting to be part of the action. What if a researcher does develop a useful technique or drug? Should industry be allowed to plunder academia, or should it pay royalties that will help fund the obscure languages department?

Some researchers have managed very well with corporate support, maintaining a relatively high level of integrity and not letting commercial powers influence the interpretation of their studies and affect their publication. A few have succumbed, and have turned their laboratory into enterprises. Some university researchers have made important advances which promote health and wellbeing worldwide. Here, industries play a key role . Some universities have hired excellent administrative staff to select and manage the promising intellectual property, and have made big bucks. To these, I say bravo. To the many universities you cite in your article who are still losing money, I say, get your act together, and learn from the universities that have succeeded.

Today, researchers and institutions need the big bucks to survive. These sometimes come from donors and commercial institutions who may try to promote their agenda. I say, take the money, if you can maintain the essence of academic curiosity and discovery, and integrity on all levels. And for those of us involved in technological advances, I add, don't forget the basic role of the university as a center for education and understanding.

Tuesday, April 29, 2008

The Moral Bankruptcy of Tel Aviv University

Tel Aviv University is having financial difficulties. As a public campus, some of the burden for this lies on the State of Israel, but some of the responsibility lies on the shoulders of those who have been running our university.

One of the most irksome issues is that of applied research. Weizmann Institute brings $100,000,000 a year from royalties of service inventions. The Hebrew University brings $40,000,000 a year. And Tel-Aviv University? Only a few millions a year. In fact, for years, most of their royalty stream derived from three service patents from my own laboratory.

I have been writing to University administrators for years, hoping that they would realize that the continued humiliation and denigration of the few professors who have succeeded in actually developing successful projects is to their own detriment. Our university has a track record of being vindictive towards its own inventors, misappropriating significant parts of their research budgets, and ridiculing their success. No wonder they bring in such paltry royalty streams.

For over twenty years, the university followed its own patent by-laws dating back to 1977. Certain sections were given an interpretation which the university sanctioned over the years. In particular, 20% of the income from patent royalties was directed to the laboratories of the inventors. However, over the past five years, the university has unilaterally begun siphoning off and misappropriating significant amounts of these research funds. According to my calculations, the university owes my laboratory over $250,000 in research funds. For all I know they have been using this money to support unrelated research, 'pet projects' or even to cover the expenses of their own management (or mismanagement, as the case may be). The university recently chose to compose a new set of patent by-laws for new inventions, which are constraining and self-defeating. The attempts of applied researchers all over campus to prevent this unilateral step were largely unheeded. A meeting scheduled months ago with the new President of the university was never held (to the best of my knowledge).

After appealing to every possible address at Tel Aviv University, from the dean of my faculty to the general manager, rector and the president of the university, with no response whatsoever, I have no recourse but to bring this to the public knowledge, by writing a series of monographs, explaining how the university has taken the low moral road. Unfortunately the problem with applied research is just the tip of the iceberg. The university's lack of moral fiber extends to its cynicism in mistreatment of its own students and its donors, and its lack of vision for the future.

I must emphasize that I love Tel Aviv University (but not its administration). My conscience will not allow me peace unless I start telling it like it is. As an employee talking out against his management, I assume that there will be repercussions. But I will no longer be silenced.

Please let me know what you think.

Mel Rosenberg, Ph.D.

Professor of Microbiology

Sackler Faculty of Medicine.